{"id":17659,"date":"2022-02-04T12:54:02","date_gmt":"2022-02-04T17:54:02","guid":{"rendered":"https:\/\/orionscoldfire.com\/?p=17659"},"modified":"2022-02-04T23:12:35","modified_gmt":"2022-02-05T04:12:35","slug":"someone-literally-cured-of-an-incurable-cancer","status":"publish","type":"post","link":"https:\/\/orionscoldfire.com\/index.php\/2022\/02\/04\/someone-literally-cured-of-an-incurable-cancer\/","title":{"rendered":"Someone Literally Cured of an Incurable Cancer"},"content":{"rendered":"

I spent over twenty years working for a company that pioneered immunological medicines, including cancer treatments.\u00a0 And with cancer treatments no one ever said cure.\u00a0 What they talk about is survival rates; % of patients surviving six months or twelve months or twenty four months.<\/p>\n

But apparently there is a cell therapy called CAR-T that has completely eliminated the cancer cells from the first two patients that were treated with it.\u00a0<\/a><\/p>\n

“I<\/span><\/span>n 2010, Doug Olson became the second person in the world to receive CAR-T cell therapy, an experimental tactic to engineer his own immune cells to fight cancer. His doctors had tempered expectations for how well it would fight off Olson\u2019s chronic lymphocytic leukemia, an incurable blood cancer \u2014 it was a last stab in the dark, one with no guarantees.”<\/strong><\/p>\n

…<\/strong><\/p>\n

\u201cWe can say it was a cure for Doug, because these are the most mature and oldest results available reported in scientific literature. Because they were the first treated,\u201d June said. \u201cTen years on, no leukemia cells, and we still have CAR-T cells that are on patrol and surveillance from leukemia.\u201d<\/strong><\/p>\n

The breakthrough is the presence after ten years of sustaining populations of functional immune cells.<\/p>\n

“Over the next several months, the data suggested that the patients\u2019 CAR-T cells were transforming from the killer CD8 T cells and into CD4 T cells, or \u201chelper\u201d T cells. These tend to remain in the body and help form a long-term immune memory, but typically are less involved in actively killing diseased cells.<\/strong><\/p>\n

In the years that followed, the CAR-T cell population did what our own natural T cells normally do: shift back and forth between types. By the nine-year mark, the researchers could only find CD4 cells, suggesting that the cells had stabilized into a long-term population of helper T cells.”<\/strong><\/p>\n

The article stated that, “There are now approved CAR-T therapies for six different indications including different types of leukemia, lymphoma, and myeloma. But nearly all other patients treated with CAR-T therapy did eventually experience a relapse of cancer, making the enduring response from these first two patients extraordinary.”<\/strong><\/p>\n

Nevertheless, this is a cancer cure.\u00a0 What can work once can be reverse engineered for other cancers.\u00a0 Hopefully the research on why this one cell therapy successfully enabled the human immune system to completely eliminate this one particular cancer can be the key to a deeper understanding of how the body defeats cancers in general.<\/p>\n

 <\/p>\n

As the Primary and General Off-Year Elections creep up on us I’m interested in getting posts from readers about their local political scene.\u00a0 Places like Texas, Colorado, Florida, Ohio, South Carolina, North Carolina, Illinois, Minnesota are represented by readers here.\u00a0 Even Canada and Australia have local political stories that some of our readers might want to provide.\u00a0 So if you are interested in sharing your perspective on your local politics, get in touch.\u00a0 Either leave a comment or send an e-mail to orionscoldfire at charter dot net.\u00a0 Anonymity is, of course, perfectly fine and if you prefer to discuss local cultural issues instead of or in addition to politics that also is encouraged.\u00a0 I’ll add this want-ad to the footer of the posts for a while to see if I can entice any readers to write.<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

I spent over twenty years working for a company that pioneered immunological medicines, including cancer treatments.\u00a0 And with cancer treatments no one ever said cure.\u00a0<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_mi_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[3545],"tags":[],"class_list":["post-17659","post","type-post","status-publish","format-standard","hentry","category-science"],"yoast_head":"\nSomeone Literally Cured of an Incurable Cancer - Orion's Cold Fire<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/orionscoldfire.com\/index.php\/2022\/02\/04\/someone-literally-cured-of-an-incurable-cancer\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Someone Literally Cured of an Incurable Cancer - 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